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Post-translational modification of proteins by glutathionylation is reversible by glutaredoxin, a thiol transferase [17]

10.1111/bdi.12416 503 ZangY.LaiX.LiC.DingD.WangY.ZhuY

In summary, MSC- and exosome-based therapies mitigate OA ferroptosis through the METTL3ACSL4, SNHG7miR-485-5pFSP1, and GOT1CCR2Nrf2 axes

Serviddio et al

Its effects require intact amylin receptor signaling, as demonstrated in receptor knockout models where weight loss is abolished, and structural studies show unique conformational dynamics at these receptors compared to native amylin or other analogs