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It is documented in hypothyroid patients treated with levothyroxine (LT4) [14], in menopause [7], central disorders of hypersomnolence (such as narcolepsy and idiopathic hypersomnia), multiple sclerosis, lupus erythematosus [15], depression [16], and celiac disease [18]

This range balances effectiveness with peptide conservation and cost considerations

Individuals with steroid-induced diabetes will often go into remission (a temporary recovery or lessening of symptoms) if they watch their diet after ending steroid therapy

However, results may vary depending on the individual and the specific cognitive issues being addressed

The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]