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Medication name: * Tri Bedoyecta Comparable patent medicine: Bedoyecta * Tri Active ingredient: hydroxocobalamin (vitamin B12), Thiamine (Vit B1), Pyridoxine (Vit B6) Presentation: Solution for Injection Concentration: 10.000 mg/100 mg/50 mg Extended-release tablets: No Lab: Grossman, S

In a mouse model of RA, ROS mediated the tolerance of B cells to autoantigens, and the mutated NCF 1 gene caused ROS deficiency, disrupting resistance to arthritis (89)

In addition, since some studies have also recorded failure in antioxidant supplementation efficacy, optimal design of clinical trials in terms of targeted delivery of antioxidants, clinical pathology and concentration dependent dosage schedule is needed to go ahead in the knowledge and future application of this kind of treatment in CIPN (Kamat et al., 2008)

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