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142 Activity-dependent mRNA translation and protein synthesis Several activity-regulated translational control pathways have been demonstrated to participate in pathologies of autism, such as the ERK/MAPK (mitogen-activated protein kinase) 143 and PI3K/mTOR (mammalian target of rapamycin) pathways

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8 weeks Result:Significantly decreased food intake, food efficiency, and water intake in db/db mice at 500 mg/kg dose

This approval represents an important milestone for the narcolepsy community, specifically for younger narcolepsy patients and their caregivers who face significant challenges associated with waking up in the middle of the night to complete treatment regimens, Greg Divis, CEO of Avadel, said in a statement

(Oxf.) 71 , 466469 (2009)