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(6) Cholinergic crisis: Excess dosing may result in severe muscle weakness and respiratory compromise, requiring urgent recognition and discontinuation of therapy

Below is a list of the significant transmitters that are released by nicotine and their subsequent effects: In the brain, activation of excitatory presynaptic nicotinic receptors results in a wide range of central effects ranging from relief of anxiety, regulation of mood, and changes in appetite, alertness, and cognition

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