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Vitamin B12 deficiency is common Vitamin B12 deficiency, along with Folate deficiency (Vitamin B9) are two of the most common causes of megaloblastic anemia

Moosmayer D, Hilpmann A, Hoffmann J, Schnirch L, Zimmermann K, Badock V, et al

Get the details in the Symptoms of B-12 deficiency section of our B Vitamin Supplements Review

Mechanistically, there is a negative correlation between KLF2 and GPX4, and KLF2 deficiency increases the level of GPX4 and inhibits ferroptosis, promoting the invasion and migration of renal cancer cells, which can be reversed by overexpression of GPX4, 150 indicating that promoting ferroptosis of cancer cells may be a promising strategy for the clinical treatment of advanced RCC

International Journal of Molecular Sciences, 25 (2), 747