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As many as 24% of men and 29% of women reported taking a supplement (either a multivitamin that contains B12, a B-complex vitamin, or a standalone B12 supplement), according to the National Health and Nutrition Examination Survey (NHANES)

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Krasel et al ., 2001), with the PKC phosphorylation enhancing the ability of GRK2 to target the plasma membrane and hence phosphorylate agonist-activated GPCRs