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For collagen synthesis, joint repair, and longevity: Longer exposures of 1216 weeks are recommended for connective tissue and skin integrity endpoints

Weight of evidence: Overall evidence is Low, some RCTs document benefits for social communication and internalizing symptoms, but findings are inconsistent across age groups and severity levels, and no study integrates redox biomarkers to confirm mechanistic effects

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Plaque ruptures and clog the blood vessels leading to lesser blood flow to heart resulting in heart stroke

Impact of novel pharmacotherapies on metabolic complications related to T2D and/or obesity A significant proportion of people with T2D have also other underlying metabolic and/or mechanical complications such as HFpEF, OSA, MASLD, CKD and knee osteoarthritis which could be improved with 1015% WL, a feasible target with the novel T2D pharmacotherapies [86]