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The PGD gene is located on chromosome 1p36.33 and is composed of 13 exons that generate three alternatively spliced mRNAs, each of which encode different sized protein isoforms

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(Anti-TPO antibodies were also reduced during the study, though this change was not considered to be statistically significant.) This study also had a meaningful impact on Vascular Endothelial Growth Factor (VEGF), a protein that stimulates the formation of blood vessels and plays a specific role in the normal function and development of thyroid cells

Participants typically start at a lower dose (1.5 mg or 3 mg in Phase 2 trials) and increase every four weeks until reaching their target dose