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The pathway leading to the formation of GSH by the action of -glutamylcysteine synthetase (GCS) is blocked by buthionine sulfoximine (BSO), inducing artificial stress condition in dHL60 cells

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10.1016/s0896-6273(00)80565-6 95 NybergG.SandersonK.AndrnP.ThrnwallM.EinarssonM.DanielsonB.et al (1996)

4.2.2 Advancements in imaging ferroptosis in myocardial ischemia Recent technological advancements have facilitated basic and clinical studies combining magnetic particles with imaging tools such as MRI to determine ferroptosis levels in ischemic myocardium

A phase 2b randomized controlled trial demonstrated the efficacy of apremilast, with PASI-75 response rates of 23.5% for the 20 mg dose and 28.2% for the 30 mg dose at 16 weeks