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It might be argued that for the long time scale of PD progression, apoptosis is an acute cellular event that on the surface does not perfectly explain the development of PD, but when patients start to have detectable parkinsonism symptoms, there is usually at least 4060% dopaminergic neuronal loss in the substantia nigra (Gigure et al., 2018), suggesting progressive accumulation of neuronal loss

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doi: 10.1016/j.biopsych.2009.09.020

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