Protandim was supplemented in 14 subjects at a dose of 1350 mg/day (double the daily dose recommended by the manufacturer) or placebo (in 16 subjects) were administered for 7 days
The combination is significantly more effective than either modality alone
In parallel, iron-handling disturbances (such as labile iron accumulation and ferritinophagy-mediated iron release) initiate a pre-ferroptotic state, lowering the threshold for ferroptotic execution upon inflammatory or mechanical insults (13,14)
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As with any supplement, consult your healthcare provider if you are on medication, pregnant, or nursing
