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The merchandising of cigarettes on a large scale became practical with the development, around the time of the First World War, of a slightly acid cigarette tobacco, which allowed smokers to inhale without an immediate unpleasant effect

After excluding multiple births, women who had high blood pressure or diabetes before pregnancy, or without information on cigarette smoking in the 3 months before and during their pregnancy, 12,150,535 mother-infant pairs was available for data analyses

Limitations A major limitation to concluding the current body of research on the cancer-related effects of e-cigarette use is the fact that, compared to other health effects, there is a lack of published studies on this topic