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An MTHFR variant does not directly measure current SAM, SAH, methylation capacity, oxidative stress, glutathione status or mitochondrial function
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89,91,92 The third category is the overtranslation of certain transcripts, which can lead to widespread epigenetic dysregulation, creating a positive feedback loop between translation and transcription processes that exacerbates neuronal dysfunction in ASD
This hydrogen bond is only possible due to the proximity of the amide group of Asn240 to the backbone (e.g