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Chronic kidney disease affects 37 million Americans, with stages 1-2 showing minimal symptoms while stages 4-5 require dialysis preparation as kidney function drops below 30%

At each time point, 20 L of iHLO culture medium was transferred to a 384-well white flat-bottom plate, 20 L of Luciferin Detection Reagent was added, and the mixture was incubated for 30 min before measuring luminescence

Medications in this category include: Metformin, H2 blockers and PPI (proton pump inhibitors) used to block acid production in the GI tract

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