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161 During aging, diverse cellular and environmental stresses are known to cause cellular senescence and chronic inflammation, both of which stimulate the release multiple inflammatory cytokines, such as IL1, IL6, and TNF, promoting further tissue damage

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[oai_citation:6PubMed]( [oai_citation:7PMC]( 5) Gastroprotective/cytoprotective actions in rodent models Multiple rat studies describe protection/healing in NSAID-induced and other gastric ulcer paradigms, consistent with mucosal cytoprotection concepts

In rodent studies, these short-chain fatty acids (such as butyrate) help strengthen the barrier protecting cells lining the colon and reduce markers of low-grade inflammation in the body

Am J Pathol 169, 861876 (2006)