In this Perspective, we propose that inhibition of ferroptosis by GPx4 provides protective mechanisms against neurodegeneration
Dysfunction of the intestinal epithelial barrier and increased permeability results in a leaky gut that is associated with intestinal disorders such as inflammatory bowel disease (IBD), bowel syndrome irritable liver disease (ILD), alcoholic liver disease, nonalcoholic fatty liver disease, steatohepatitis, liver cirrhosis, and collagen diseases (Figure 2)
Mechanistically, the upregulation of OCTN2 promotes the proliferation and migration of HCC cells in vitro and augments the growth and metastasis of HCC, as well as the cancer stem-like properties of HCC by increasing FAO and OXPHOS, which depends on PGC-1 signaling
Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)
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