The docking cavity was centred on the sulfur atom of the GSHs cysteine and allowed to extend in a spherical surrounding region with a 15 radius
[DOI] [PubMed] [Google Scholar] 314.Guerriero E., Capone F., Accardo M., Sorice A., Costantini M., Colonna G., Castello G., Costantini S
In mammalian nervous systems, many different types of chemical substances, including amino acids (e.g., glutamate), monoamines (e.g., dopamine, norepinephrine), acetylcholine, peptides (e.g., substance P), serve as neurotransmitters to bind their corresponding receptors, then activate ion channels, and consequently produce ion flux 1 , thereby inducing membrane potential changes that lead to signal propagation for neurotransmission 1,2,3,4
In contrast, individuals who develop malabsorption of vitamin E in adulthood may not develop neurological symptoms for 10 to 20 years
However, we wanted to compare the array method to more conventional methods of identifying glutathionylated proteins using BioGEE, for example, by mass spectrometry following affinity purification on streptavidin beads 17,25
