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In addition to mTORC signaling, CUL5 promotes the ubiquitination and degradation of p62 by forming a complex with ASB6a protein containing a C-terminal SOCS box motifthereby enhancing autophagy in hepatocellular carcinoma (129)

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Moreover, certain COF-based systems can further potentiate antitumor immune responses, enabling combinational immunotherapy

Gougeon, A.: Regulation of ovarian follicular development in primates: Facts and hypotheses, Endocr