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This finding can be explained by our structure, because in the presence of a disulphide between Cys73 hTrx1 and Cys73 hTrx1 , the hTrx1 residues 73 hTrx1 to 75 hTrx1 , which are involved in binding of hTrx1 to hTrxR1 (see above), are not available for hTrxR1hTrx1 complex formation (Fig

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Follow-up labs usually confirm resolution within a few months, though patients with recurring symptoms may eventually switch to methylcobalamin for its additional cellular benefits

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The study did not qualify for prospective registration as a clinical trial because there was no study directed intervention