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When tested at 10 M, -Glu-Glu was the only one among the - L-Glu-AAs tested to elicit significant excitatory action evidenced by a Ca 2+ increase (68.5 11.10% after normalizing the response elicited by the dipeptides to the response induced by 10 M glutamate

In the past twenty years, and mainly by repurposing drugs use, molecules have been identified but to date, clinical trials display moderated efficiency

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Glass SB, Gonzalez-Fajardo L, Beringhs AOR, Lu X

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