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By targeting the inflammatory pathways involved in the disease, these therapies aim to reduce inflammation, oxidative stress, and the release of pro-inflammatory mediators in the renal tubules

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This conformational change further transduces through F279 6.51 and H280 6.52 to cause rearrangement of an aromatic cluster formed by residues W276 6.48 , F279 6.51 , H280 6.52 , and F312 7.42 (Fig

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4 Ryser JE, Farquet JJ, Petite J