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Large-molecule biologics are not subject to the protein-displacement interactions that affect small molecules

IGF-1 induces skeletal muscle hypertrophy through activation of satellite cells and enhanced protein synthesis. Adams, G.R., American Journal of Physiology-Endocrinology and Metabolism 2

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When combined with alpha-lipoic acid, some early research has shown that benfotiamine may enhance effects in reducing pain and improving nerve conduction in people with diabetic neuropathy.8 The synergy likely stems from their complementary mechanisms: benfotiamine helps manage glucose-induced damage, while ALA reduces oxidative stress and improves blood flow

You may experience side effects, while others may not