PHHs have been widely used in clinical trials which easily lose functions during cell isolation, culture, and cryopreservation (Sun et al., 2023)
Post-COVID Syndrome and Gastrointestinal Involvement While respiratory manifestations initially dominated the COVID-19 clinical picture, research now demonstrates that SARS-CoV-2 affects multiple organ systemsparticularly the gastrointestinal tract
Given the significant decrease in S-palmitoylation of ATG2 induced by glucose and serum deprivation, as well as Torin 1 treatment, it is plausible that alterations in modifications to either ZDHHC11 or ATG2A mediated directly or indirectly by mTOR may play a role in this process
This mechanism was documented in humans in 1984 by Bowers and confirmed in multiple clinical studies (Nass et al., J Clin Endocrinol Metab 2008)
Wang H, Zhou Y, Zhuang W, et al