EMBO Mol Med 15(9):e17399
gasseri -treated mice exhibited reduced body weight loss, lower DAI scores, restored colon length, and alleviated pathological damage compared to mice treated with DSS alone (Fig
Using an adeno-associated virus as a vector, OSK was precisely delivered to senescent cells with a highly active Cdkn2a promoter, an important marker of cellular senescence
A high-performance anti-aging water-texture cream powered by Copper Tripeptide-1 (GHK-Cu), Bakuchiol (a plant-based retinol alternative), and Ceramides to visibly firm skin and reinforce the moisture barrier
FIGURE 5 4.4 Epigenetic regulation of drug resistance In the epigenetic regulatory network of gemcitabine resistance, long noncoding RNA (lncRNA) mediated RRM2 regulation and dynamic regulation of drug-metabolizing enzymes by m 6 A (N6-methyladenosine) methylation modification are two key mechanisms that together constitute a complex resistance network: In the mechanism of gemcitabine resistance, oncogenic lncRNAs (such as MALAT1 and NEAT1) significantly promote the expression of ribonucleotide reductase M2 (RRM2) through epigenetic regulation (Wang et al., 2021)
