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Profound Fatigue and Post-Exertional Malaise (PEM): Alpha lipoic acid and magnesium directly support the mitochondrial Krebs cycle, facilitating the efficient conversion of glucose into ATP

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The reduced form, NADPH is used by all forms of cellular life as an electron donor as part of many biosynthetic reactions

Factors Indicating Against Dose Escalation Maintain current dose when experiencing significant side effects at present level, achieving satisfactory subjective improvements (better sleep, energy, recovery), IGF-1 increased adequately (50+ ng/mL) for optimization goals, or financial constraints make higher dosing unsustainable