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References Jiang F, Wu Y, Liu Z, Hong M, Huang Y

They need to be present consistently to maintain the gene expression changes that drive collagen synthesis

The peptide works through multiple mechanisms including enhanced angiogenesis (blood vessel formation), increased collagen synthesis, and activation of growth hormone receptors on fibroblasts

doi: 10.1038/s41422-022-00653-7 272 TangamornsuksanW.LohitnavyO.SruamsiriR.ChaiyakunaprukN.Norman ScholfieldC.ReisfeldB.et al

These include alpha-lipoic acid (100 to 200 mg daily), methylsulfonylmethane (MSM) at 500 mg three times a day , and milk thistle supplements rich in silymarin