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Acute effects of butyrate on induced hyperpermeability and tight junction protein expression in human colonic tissues

The beneficial effect of caffeine in reducing memory impairment by regulating the expression of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) or by regulating the expression of nuclear erythroid 2-related factor (Nrf2) and Toll-like receptor 4 (TLR 4)-induced glial cells-mediated neuronal cell death and neuroinflammation [46]

Freeman, 2017)

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An implication therefore is that CFTR function is directly linked to pulmonary neuroendocrine function