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The GLP-1 and GIP arms slow gastric emptying and blunt appetite (that is where nausea comes from), while the glucagon arm nudges energy expenditure and hepatic fat handling

10.1016/j.aspen.2016.07.013 145 KimD.-H.HanS.-M.ChoiY.-S.KangH.-K.LeeH.-G.LeeK.-W

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Published safety data shows negative results in repeated-dose toxicity studies, skin irritation protocols, sensitization assays, and genotoxicity testing

Pickart holdS the patent on GHK and 2nd generation copper peptides