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The dosing schedule should be determined by a healthcare provider, with periodic monitoring of vitamin B levels and clinical symptoms to adjust therapy as needed

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Additionally, medications commonly used alongside or after bariatric surgery, such as proton pump inhibitors (PPIs) and metformin, can independently reduce B12 absorption and may necessitate closer monitoring

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Three strength combinations are available: 2 mg semaglutide / 0.1 mg methylcobalamin (starting dose) 5 mg semaglutide / 0.1 mg methylcobalamin (intermediate dose) 12 mg semaglutide / 0.1 mg methylcobalamin (higher dose) The methylcobalamin dose remains constant at 0.1 mg (100 mcg) across all three strengths