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Nature 630(8016):493500

We found that PPARa over-expression significantly up-regulated FSP1 expression in neuron after TSCI, thus promoted the expression of CoQ10 and content of NADH, while icFSP1 inhibited this phenomenon, suggesting that FSP1 is a key effector of PPARa mediated lipid peroxidation related neuronal ferroptosis protection

Submitters also called for longer implementation in either Australia or New Zealand depending on the degree of change to current regulatory practices

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6.3.2 Abnormal fatty acid oxidation It should be noted that FAO abnormalities have cell-type specificity human bronchial epithelial cells exposed to short-term cigarette smoke (CS) or treated with cigarette smoke extract (CSE) show upregulated FAO and increased expression of carnitine palmitoyl transferase 1A (CPT1A), the rate-limiting enzyme of FAO, thereby promoting FAO-mediated ROS production and cell death, and participating in the development of emphysema (33)