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Future studies incorporating more comprehensive dietary intake data are needed for further validation

The precise mechanisms driving altered metabolic pathways in ME/CFS, GWS, and FM remain to be elucidated

Growing evidence from animal and human studies shows that structural pathology, network, and connectivity dysfunction related to deficits in excitatory glutamate neurons and inhibitory GABA interneurons in the cortical and limbic areas of the brain are implicated in the genesis of depressive symptoms

Clinical studies involving minnelide are ongoing, and no results have been reported

The direct infusion of nutrients addresses deficiencies more efficiently than oral supplements, which might not be fully absorbed due to gastrointestinal issues common in these patients