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A growing body of evidence has reported that Nrf2 participates in regulating ferroptosis by promoting the expression of downstream genes[40], such as FTH1, SLC7A11, and HMOX1, most of which exert a negative regulatory effect against ferroptosis by promoting the synthesis of GSH, reducing ROS production, and upregulating NADPH expression

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Research Applications Aging Reversal and Healthspan Extension FOXO4-DRI demonstrates remarkable efficacy in reversing multiple hallmarks of aging and extending healthspan in preclinical models

however, their GLUT2 expression also was decreased by infection (97)

Benefits depend on consistency, nutrition, and lifestyle habits Stopping use may gradually reduce visible effects Sun exposure, stress, and diet can influence long-term results Maintaining healthy habits helps support longer-lasting outcomes.