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The potential irritation can be minimized by adjusting the pH of the nasal formulation to 4.56.5 to match the normal pH of the nasal mucosa (Vidyavathi et al., 2021)
doi:10.1007/s00228-015-1873-4 Wirtz PH, Spillmann M, Brtschi C,Ehlert U, von Knel R
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