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The determination of hydrodynamic diameter and PDI is very difficult in the case of multi-armed polymers, because the non-spherical shape of nanocarriers is one of the limitations of dynamic light scattering measurement technique [57]

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After 5 min, transformation to cyanmethemoglobin is complete at room temperature

Both berberine and QLQX have favorable safety profiles in trials, but real-world use requires vigilance: Hepatic and Renal Function: Berberine has not been associated with liver enzyme elevations or hepatotoxicity in clinical studies

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