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Finally, the potential role of CD44, a surface receptor involved in cell-extracellular matrix interactions and migration, was examined

Beveridge et al., 2013

Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1

That means we also have a huge issue with histamine inside the cells

Week 8-12: Significant overall improvement for responders