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This results in the transcriptional upregulation of pro-inflammatory cytokines (IL-1, TNF-, IL-6) [32], chemokines (CXCL8/IL-8, CCL2), antimicrobial peptides, and co-stimulatory molecules that enhance immune cell recruitment and activation [34]

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2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on